Microbicides 2004 Microbicides 200428-31 March 2004, Hilton London MetropoleThe conference42 million men, women and children worldwide were living with HIV by the end of December 2002 (source: UNAIDS), including five million newly-infected during that year alone. Another 45 million people will become infected between 2002 and 2010, unless the current transmission rates can be vastly reduced. Of the 42 million, 29.4 million live in sub-Saharan Africa and 58% of them are women. Not only are women more susceptible to HIV infection, many are powerless to insist on the use of condoms or other methods of protecting themselves. In this context, and with the knowledge that an effective HIV vaccine is unlikely to be available for several years, the need for an effective topical microbicide grows ever more urgent. 2004 should prove to be a landmark year in the field of microbicide development as the first Phase III trials of novel products are due to start – the next step along the road to making a microbicide available to the millions worldwide in desperate need of protection.The aims of the Microbicides 2004 conference are to:Report novel or innovative work in the microbicides fieldProvide updates on recent microbicides research, divided into three tracks: basic science, clinical science, and behavioural science (including public health and the microbicide marketplace)Provide a forum for the discussion of new developments in microbicide research including ethical, clinical, behavioural and methodological issuesPresent opportunities for knowledge-sharing between microbicide researchers, public-health workers and advocacy organisations.There will be an opening ceremony on the evening of Sunday 28 March at which politicians, policy makers and the international media are expected. The conference will run for a full three days, each of which will contain:Scientific overviews and presentations with plenary sessions, invited lecturers and presentations of original researchWorkshops to review issues unique to microbicides such as trial design and outcome measures, and ethical issues in the clinical trials of microbicidesPoster sessions. Focus on LondonFollowing the successful Microbicides conferences in Washington in 2000 and Antwerp in 2002, March 2004 sees the focus move to London.The venue is the Hilton Metropole Hotel, two minutes by taxi from Paddington station and the Heathrow Express, with a journey time from the airport of 15 minutes. The hotel is in walking distance of Hyde Park and London’s main shopping streets, and close to Imperial College. Accommodation will be available at the venue and other hotels in the vicinity.London in March offers a variety of diversions for out-of-conference relaxation, including sight-seeing and shopping; the arts and the theatre; and pubs, clubs and restaurants to suit every taste. Conference staff will be on hand to help delegates plan their spare time.To book your place or find out more information, e-mail info@microbicides2004.org.uk or telephone the Event Office on +44 (0) 20 7720 4411
Oral: invited speaker Oral: Track A Oral: Track B Oral: Track C Poster: Track A Poster: Track B Poster: Track C Abstract only Authors

02229_1 SEX HORMONE RECEPTOR, ADHESION MOLECULE AND ANTIBODY PRODUCTION IN ANTIBOBY-SECRETING CELLS

Cao, Xiaomei
Yu M, Wang X, Xu J, Ben K
Kunming Institute of Zoology, CAS, China

Local immunity in the genital tracts is important in protection from sexually transmitted pathogens, and in immunological fertility regulation. Our previous study showed that sex hormones play an important role in regulation of the migration of circulating antibody-secreting cells to genital tracts. This regulation may be caused by complementary adhesion molecules expressed on the antibody-secreting cells and on the endothelium of venules. To understand the mechanism that sex hormones regulate the migration of antibody-secreting cells to genital tracts and the effect of sex hormones on antibody production in mucosal associated tissues, we selected mouse SG2 and PA4 hybridoma cells respectively secreting IgG2b and polymer IgA, and used RT-PCR for detecting expression of sex hormone receptor and CXCR4 mRNA in the SG2 and PA4 cells. The expression of surface molecular markers was measured by flow cytometry, and antibody production of SG2 and PA4 cells was determined by ELISA. Androgen receptor (AR), estrogen receptor? and CXCR4 mRNA were found in SG2 and PA4 cells, but CD31 were not expressed on these cells. The effects of sex hormones on the expression of surface molecular markers and antibody production in SG2 and PA4 cells were not obviously demonstrated. These results suggest that the adhesion molecules on the antibody-secreting cells are not associated with sex hormone regulation on the migration of these cells to genital tracts. Therefore, the migration regulation by sex hormones is most likely expected to be caused by the addressins on endothelial cells.

Research professor, Xiaomei Cao
Rm 3-6-402, Global Village, Hightech District, Kunming, Yunnan 650106, P. R. China
(Telephone) 0086-0871-832-1588 (Fax) 0086-0871-832-1588 (E-mail) kben@mail.kiz.ac.cn